All the sons and daughters appear to have been of high character, but it is only of four sons and one daughter that we have any special record. The daughter, called Macrina, from her grandmother, was the angel in the house of this illustrious family. She shared with her grandmother and mother the care and education of all its younger members. Nor was there one of them who did not owe to her religious influence their settlement in the faith and consistency of Christian conduct.
This admirable woman had been betrothed in early life, but her intended husband died of fever. She permitted herself to contract no other alliance, but regarded herself as still united to her betrothed in the other world. She devoted herself to a religious life, and eventually, with her mother Emmelia, established a female conventual society on the family-property in Pontus, at a place called Annesi, on the banks of the river Iris.
It was owing to her persuasions that her brother Basil also gave up the worldly life, and retired to lead the devout life in a wild spot in the immediate neighbourhood of Annesi. Here for a while he was an hermit, and here he persuaded his friend Gregory Nazianzen to join him. They studied together the works of Origen, and published a selection of extracts from his Commentaries, which they called "Philocalia." By the suggestions of a friend Basil enlarged his idea, and converted his hermit's seclusion into a monastery, which eventually became the centre of many others which sprung up in that district.
His inclination for the monastic life had been greatly influenced by his acquaintance with the Egyptian monks, who had impressed him with the value of their system as an aid to a life of religious devotion. He had visited also the hermit saints of Syria and Arabia, and learnt from them the practice of a severe asceticism, which both injured his health and shortened his days.
Gregory of Nyssa was the third son, and one of the youngest of the family. He had an elder brother, Nectarius, who followed the profession of their father, and became rhetorician, and like him died early. He had also a younger brother, Peter, who became bishop of Sebaste.
Reference address : https://www.elpenor.org/nyssa/life-works.asp?pg=2