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A charge of uncanonical irregularity in his ordination is brought up against him by certain Arian Bishops, and he is summoned to appear and answer them at a Synod at Ancyra. To this was added the vexation of a prosecution by Demosthenes, the Emperor's chef de cuisine, on a charge of defalcation in the Church funds.
A band of soldiers is sent to fetch him to the Synod. The fatigue of the journey, and the rough treatment of his conductors, together with anxiety of mind, produce a fever which prevents his attendance. His brother Basil comes to his assistance. He summons another Synod of orthodox Cappadocian Bishops, who dictate in their joint names a courteous letter, apologising for Gregory's absence from the Synod of Ancyra, and proving the falsehood of the charge of embezzlement. At the same time he writes to solicit the interest of Astorgus, a person of considerable influence at the Court, to save his brother from the indignity of being dragged before a secular tribunal.
Apparently the application was unsuccessful. Demosthenes now obtains the holding another Synod at Gregory's own See of Nyssa, where he is summoned to answer the same charges. Gregory refuses to attend. He is consequently pronounced contumacious, and deposed from his Bishopric. His deposition is followed immediately by a decree of banishment from the Emperor, a.d. 376. He retires to Seleucia. But his banishment did not secure him from the malice and persecution of his enemies. He is obliged frequently to shift his quarters, and is subjected to much bodily discomfort and suffering. From the consoling answers of his friend Gregory of Nazianzen (for his own letters are lost), we learn the crushing effects of all these troubles upon his gentle and sensitive spirit, and the deep despondency into which he had fallen.
At length there is a happier turn of affairs. The Emperor Valens is killed, a.d. 378, and with him Arianism vanished in the crash of Hadrianople.' He is succeeded by Gratian, the friend and disciple of St. Ambrose. The banished orthodox Bishops are restored to their Sees, and Gregory returns to Nyssa. In [6] one of his letters, most probably to his brother Basil, he gives a graphic description of the popular triumph with which his return was greeted.
But the joy of his restoration is overshadowed by domestic sorrows. His great brother, to whom he owed so much, soon after dies, ere he is 50 years of age, worn out by his unparalleled toils and the severity of his ascetic life. Gregory celebrated his death in a sincere panegyric. Its high-flown style is explained by the rhetorical fashion of the time. The same year another sorrow awaits him. After a separation of many years he revisits his sister Macrina, at her convent in Pontus, but only to find her on her death-bed. We have an interesting and graphic account of the scene between Gregory and his dying sister. To the last this admirable woman appears as the great teacher of her family. She supplies her brother with arguments for, and confirms his faith in, the resurrection of the dead; and almost reproves him for the distress he felt at her departure, bidding him, with St. Paul, not to sorrow as those who had no hope. After her decease an inmate of the convent, named Vestiana, brought to Gregory a ring, in which was a piece of the true Cross, and an iron cross, both of which were found on the body when laying it out. One Gregory retained himself, the other he gave to Vestiana. He buried his sister in the chapel at Annesi, in which her parents and her brother Naucratius slept.
[6] Epist. III. (Zacagni's collection).
Reference address : https://www.elpenor.org/nyssa/life-works.asp?pg=7